polymyxins

Map Branches

• inhibitors of protein synthesis
  • act on 30S
    • aminoglycosides (strepto-mycin, gentamycin
    • tetracyclines
  • act on 50S
    • chloramphenicol
    • clindamicin
    • erythromycin
• inhibitors of cell membrane function
  • for bacteria
    • polymyxins
  • for fungi
    • polyenes (amphotericin B, nystatin-topical)
    • azoles (ketoconazole-oral, miconazole-topical, fluconazole)
• inhibitors of nucleic acid synthesis
  • flucytosine
  • rifampin
  • metronidazole
  • quinolones (nalidixic acid, ciprofloxacin, norfloxacin)
• inhibitors of metabolism
  • isoniazid
  • trimethoprim
  • sulfonamides
• inhibitors of cell wall synthesis
  • bacitracin
  • vancomycin
  • B-lactam antibiotics

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