not all peptides exist in thymus

Map Branches

• alpha-beta
  • CD 8 cytotoxic
    • Th1 cytokine profile
    • kills infected cell lysomes
      • perforin
      • granzymes
    • co stim = CD 28 + 86
    • respond to fas ligand
      • suicide
  • CD 4 helper
    • Th0 naive
      • differentiate w/ APC cytokines + CD 86, MHC + peptide
        • IL12
          • Th1
            • bact. inf.
              • inflammation
            • B class switch
              • IgG
            • inhibit Th2
            • MO
              • ROS
              • + MHC
              • divide
            • sensitivity
        • IL 10
          • Th2
            • B class switch
              • IgG
              • IgE
              • IgA
            • - MO
            • inhibit Th1
            • + mast
            • + eosino
            • allergy
        • IL 10 mucous
          • Th3
            • inhibit Th1 + Th2
            • oral tolerance
              • anergy
              • deletion
              • Th3
              • dose
                • high
                  • deletion
                • low
                  • Th3
  • recognize MHC + peptide
  • development
    • thymus as double positive
    • not specific
    • dend. filter (MHC I + II available)
    • bind to MHC
      • I
        • CD 8
      • II
        • CD 4
    • down reg. other CD
    • single positve
• tolerance
  • central
    • look at thymus self peptide
      • no binding
        • DUD
          • deathrow
      • strong bind to peptide
        • deletion
      • fit MHC, low peptide
        • live
          • exit
  • peripheral
    • keep T in check
      • not all peptides exist in thymus
    • 2 signal hypothesis
      • 1
        • MHC + peptide
      • 2
        • co-stimulation
          • CD 86 on APC (danger sig.)
            • only expressed from TLR stimuli during infection
          • CD 28 on T
      • only 1
        • anergy
• misc.
  • V-J rearrangement
  • one binding site
  • no receptor editing
  • no som. hypermut.
• gamma-delta
  • innate like
  • present without infection
  • no thymus/lymph travel
  • recognize whole antigen
  • mucous
  • ancient

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