Phases of Disease Progression

Map Branches

• Normal flow, healthy tissue
  • Flexibility
  • Rapid response to demand
• Tissues lose integrity
  • Glycation
  • Chronic stress
  • Hormonal changes
  • Chronic inflammation
  • Obesity and stasis
  • Nutritional deficiency
• Additional insult
  • Injury to local tissues
  • Infection -- e.g. h. pylori
  • Free radical damage -- e.g. smoking
• Inflammatory response (simplified version)
  • Release of cytokines
  • Infiltration of macrophages
  • Appearance of foam cells
  • Formation of fibrous tissue
  • Infiltration by platelets
  • Adherence of cholesterol
  • Adherence of calcium
• Late stages
  • Occlusion
  • Thrombosis
  • Hemorrhage
  • Surface defect

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