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EMF and DNA: Learning from Henry Lai, Martin Blank, Jerry Phillips and others...

EMF and DNA>

Mind Map branch: EMF and DNA: Learning from Henry Lai, Martin Blank, Jerry Phillips and others... EMF and DNA:
Learning from 
Henry Lai, Martin Blank, 
Jerry Phillips
and others... Studies http://www.ncbi.nlm.nih.gov/pubmed/19811402 ELF, strand breaks http://www.ncbi.nlm.nih.gov/pubmed/20070213 Microglial activation http://www.ncbi.nlm.nih.gov/pubmed/19879861?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2 Mitochondrial DNA http://www.emf-portal.de/viewer.php?aid=12253&l=e Increase in micronuclei http://www.ncbi.nlm.nih.gov/pubmed/8480633 Review of early studies http://www.buergerwelle.de:8080/helma/twoday/bwnews/stories/385/ ELF, DNA fragmentation http://www.ncbi.nlm.nih.gov/pubmed/19833226 RF/MW poor DNA repair http://www.ncbi.nlm.nih.gov/pubmed/14990889?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=13 Inhibition of DNA synthesis http://www.ncbi.nlm.nih.gov/pubmed/20353343 Mutagenic effect on rat brain http://www.ncbi.nlm.nih.gov/pubmed/18175330?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5 Alteration during cell division http://www.ncbi.nlm.nih.gov/pubmed/2423839 Nuclear substance alterations http://www.emf-portal.de/viewer.php?aid=2066&l=e ELF, chromosomal aberrations http://www.avaate.org/IMG/pdf/Kanaca_et_al_2011.pdf RF, genotoxic effect on rat brain http://www.ncbi.nlm.nih.gov/pubmed/15988145?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=8 Increased mutagenicity of X-ray http://www.emf-portal.de/viewer.php?aid=16966&l=e MF, DNA, chromosomal damage http://www.technologyreview.com/blog/arxiv/24331/ Terahertz waves tear apart DNA http://www.emf-portal.de/viewer.php?aid=14327&l=e Increase in chromatid exchanges http://www.ncbi.nlm.nih.gov/pubmed/8373813 Membrane not required for study http://www.ncbi.nlm.nih.gov/pubmed/10630622 ELF, EMF transcription, translation http://www.ncbi.nlm.nih.gov/pubmed/19649291 Mobile phone, sperm DNA damage http://www.ncbi.nlm.nih.gov/pubmed/17579989 RF/MW mammal spermatozoa DNA http://www.ncbi.nlm.nih.gov/pubmed/15869902 RF/MW Non-thermal DNA breakage http://www.ncbi.nlm.nih.gov/pubmed/12859147?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=15 Discussion of care required in studies http://www.emf-portal.de/viewer.php?sid=&sform=&aid=9990&l=e ELF, DNA single, double strand breaks http://www.hese-project.org/de/emf/WissenschaftForschung/Gadhia_Prof.%20Dr._P.K./A%20preliminary%20study%20to%20assess%20possible%20chromosomal%20damage.pdf Chromosomal damage, mobile phones http://www.ncbi.nlm.nih.gov/pubmed/21500233?dopt=Abstract ELF, human lymphocyte chromatin effect http://www.ncbi.nlm.nih.gov/pubmed/20824388 ELF-EMF, oxidative stress, DNA, apoptosis http://www.ncbi.nlm.nih.gov/pubmed/21504343 ELF, chromosome gene transposition activity http://08189099965995884056-a-g.googlegroups.com/attach/1d7adb8bf57c081b/Genotoxicity_to_Mouse_Brain.pdf?gda=oz1_aEUAAACAVmdJNRotPCEDnyCSMrMHMz6_3-T9Qe3XT5-kGY2QKxmte4pmveJ6fFYYkUl727mO3f1cykW9hbJ1ju6H3kglGu1iLHeqhw4ZZRj3RjJ_-A&view=1&part=2 Genotoxic effect of RF on mouse brain, DNA http://www.ncbi.nlm.nih.gov/pubmed/20816755 60 Hz, DNA double-strand breaks, apoptosis http://www.ncbi.nlm.nih.gov/pubmed/15099821?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=12 Increased mutagenicity of hydrogen peroxide http://www.ncbi.nlm.nih.gov/pubmed/12524674?dopt=Abstract Mobile phones, epigenetic alterations in WBCs http://www.ncbi.nlm.nih.gov/pubmed/18278508 Genotoxic effects in fibroblasts, not lymphocytes http://www.ncbi.nlm.nih.gov/pubmed/21457072 New hypothesis:
DNA is a fractal antenna, sensitive to electromagnetic fields DNA, RNA activation without damage http://www.ncbi.nlm.nih.gov/pubmed/20070213?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1 Inflammation increased http://www.ncbi.nlm.nih.gov/pubmed/11424156?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=21 Increased stress response http://www.ncbi.nlm.nih.gov/pubmed/11887334?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=19 Oncogene overexpression http://www.laserfocusworld.com/articles/2011/09/potential-biological-effects-of-terahertz-radiation-studied.html Terahertz changes gene expression http://www.ncbi.nlm.nih.gov/pubmed/16116041?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=7 Increased transcription, apoptosis factors http://www.buergerwelle.de:8080/helma/twoday/bwnews/stories/385/ mRNA upregulation, injury-associated proteins http://www.sciencedirect.com/science/article/pii/S0928468009000066 EMF activation of DNA changes, cellular stress response Newer studies http://www.ncbi.nlm.nih.gov/pubmed/20156525 MW, astrocytes, DNA fragmentation http://www.ncbi.nlm.nih.gov/pubmed/22112647 Computers, Wi-Fi, DNA fragmentation http://www.ncbi.nlm.nih.gov/pubmed/22047462 ELF, mouse embryo, DNA fragmentation Other links http://www.tbnewswatch.com/entertainment/82393/Wireless-concerns Article:  Wireless Concerns http://www.emf-portal.de/searchfunc.php?l=e EMF-Portal publication query http://www.novamind.com/connect/nm_documents/show_branch/Power/CE015A63-BFC0-4563-8DD5-8F7162AF3EFF/501614168 Map on EMF, Free Radical Activity http://www.laserfocusworld.com/articles/2011/09/potential-biological-effects-of-terahertz-radiation-studied.html http://macedoniaonline.eu/content/view/17090/56 Terahertz radiation affects DNA http://edoc.unibas.ch/1026/1/Doktorarbeit_final_new.pdf Insights into genotoxic effects of EMF http://www.youtube.com/watch?v=DR682Efqy7k Dr. Martin Blank, video on DNA breaks http://www.thehindu.com/news/national/article1033086.ece?homepage=true Article, mobile phones, DNA strand-breakage http://pdfcast.org/pdf/analyzing-the-health-impacts-of-modern-communications-microwaves Panagopoulus:  Health Impacts, Microwaves http://physics.aps.org/synopsis-for/10.1103/PhysRevLett.106.248103 Brief intro. to study, DNA collapse in electric field http://electricwords.emfacts.com/index-DNA.html EMF Health-effect Research:  Genes and DNA Studies DNA damage:  
Dr. Lai's work,
Dr. Phillips' work http://electromagnetichealth.org/audio-archives-and-more/ Audio Presentations on DNA damage http://www.ncbi.nlm.nih.gov/pubmed/19264461 Dr. Phillips:  EMF, DNA damage survey http://www.bioinitiative.org BioInitiative:  See Section 6:  Genotoxic Effects http://www.scribd.com/doc/21750937/EMF-Cell-Phone-DNA-Damage Dr.'s Lai, Singh, Phillips:  EMF and DNA damage http://www.chelationtherapyonline.com/NewCancerScience/ns2.htm Dr.'s Lai and Singh:  DNA damage in rat brain cells

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DNA/RNA/GENE
Functional changes

More inflammation
Earlier death
Reduced growth
More tumor potential

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DNA/RNA/GENE
Structural changes

Single strand breaks
Double strand breaks
Slower repair
Formation of micronuclei
Sister chromatid exchanges

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THE FENTON REACTION

This is a reaction between iron (present in body tissues, especially the brain) and hydrogen peroxide (a product of oxidation, high in tissues with many active mitochondria) to make highly reactive hydroxyl radicals. This is believed by some to be an explanation for the particular tissues most sensitive to free radical DNA damage from EMF (with its effect on iron and magnetite) and carcinogenesis.

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"There is no consistent pattern that radiofrequency radiation exposure could induce genetic damages/changes in cells and organisms. However, one can conclude that under certain conditions of exposure, radiofrequency radiation is genotoxic....critical genetic mutations in one single cell are sufficient to lead to cancer..."

Henry Lai

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DIFFICULTY ASSESSING DNA EFFECTS

Molecules are small
Effects appear to be nonlinear
There are few experts in assessment techniques
Descriptions of experimental protocols are often poor
Very small changes may be highly significant

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Complexity of DNA replication

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EMF penetrates and affects cellular structures

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