Paget's Disease (Aka Osteitis Deformans)

Map Branches

• 3 Stages
  • Osteolysis = Fibrous bone resorption
  • OsteoBlastic = Hectic bone formation
  • Osteosclerosis
  • Results increase Bone Mass
    • Bone poorly structured & Weak
      • Onset = Mid Adulthood
        • Common Whites of US
          • Asymptomatic
• Morphology
  • Coarse Thickened Trabeculae
    • Soft cortex and Porous
      • Vulnerable to pathological fracture
• Clinical Course
  • Discovered in accidental xray findings
  • Elevated serum Alkaline Phosphatase
  • Axial Skeleton involved in 80% of cases
  • Found in Pelvis, Spine, Skull = 85%
  • No bone is immuned
  • Rare in Rib, Fibula, Small bones of hands and feet
  • Localized Pain = Common Problem
  • Skull Involvement
    • Result in Platybasia (flattening of base of Skull)
      • Nerve Root Compression
  • Lower Extremity Involvement
    • Severe 2o Osteoarthritis
    • Bowing Deformity
    • Pathological Fracture = Chalk Stick
  • Spine Involvement
    • Compression Fractures of VB
      • Kyphosis development
  • Tumor and Tumor like conditions form in Paget's bone
    • Typically Benign lesions
      • Sarcoma = 0.7-0.9%
        • Not life threatening Except with SARCOMA
• Pathogenesis
  • Slow virus infection of Paramyxovirus
  • Hereditary component = Chromosome 18Q

Comments

► Comments for document "CNS Infections"

	Kathleen Sundmark almost 3 years ago	Great info. Lots of work. Thank you for these maps. They represent a lot of information and a great deal of work.

	Edward Shekhter almost 3 years ago	Re: Great info. Lots of work. Thank you. Just got NovaMind about 3 weeks ago. This is my first go at it. There is so much information, but I am not sure if the way I presented/did this is the best way. Also I am looking for more insight and better way to do these mind maps, from experienced people.

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