Association with HLA B27

Map Branches

• Disease Of Joints (DIM)
  • Degenerative (DOS)
    • Diffuse idiopathic skeletal hyperstosis = DISH (Aka Forestier's Disease)
    • Osteoarthritis
    • Spondylosis
  • Inflammation (Ends Joint Ankylosis) (RS)
    • Rheumatoid Arthritis
    • Seronegative Spondyloathritides
      • Ankylosing Sponylitis
      • Psoriatic Arthritis
      • Reiter's Syndrome
      • Arthritides Associated with:
        • Inflammation of Bowel Disease
      • Infectious Arthritides
      • Reactive Arthritides
        • NOT SERONEGATIVE
  • Metabolic = Crystal (COG)
    • Chondrocalcinosis = 2ndry Arthritis
    • Ochronosis
    • Gout
• Inflammatory Joint Disease (Aka Arthritis = Inflammation of Joint)
  • Primary Target = SYNOVIAL MEMBRANE
  • Progressive stages in inflammatory joint pathology (Rheumatoid Arthritis) Also for FINAL Lecture Exam
    • Inflammation of Synovial Membrane
    • Narrowing of Joint
    • Dramatic dmg to joint = articular cartilage (Destruction of Bone)
    • Leads to Fusion of Joint = Joint Anklyosis
    • All joints of body are vulnerable
      • Inc. Middle Ear
        • CERVICAL SPINE ALWAYS INVOLVED
          • Does not affect Dorsal or Lumbar Vertebra
      • Sometimes many Organs and Tissues involved throughout body
  • Seronegative spondyloarthritides( NO Rheumatoid factor)
    • Rheumatoid factor = Special immune Complex
    • Absence of Rheumatoid Factor
    • Not same as Rheumatoid arthritis
    • Pathological changes begin in Ligamentous Attachments to bone
      • Rather then Synovium
      • Enthesis = Insertion Fibrous structure to BONE
        • Stuctures that create Enthesis
          • Ligament
          • Joint Capsule
          • Fascia
          • Tendon
        • Properties of Enthesis (all 3 to be called Enthesis)
          • Rich with Nociceptors
          • Poor Blood Supply
            • Poor Healing
      • Synovial joints of Spine
        • Zygapophyseal Joint
        • Costotransverse Joint
        • Costoverteral Joint
        • Atlantodental Joint
        • Atlanto-occipital Joint
        • Sacroiliac Joint
    • Frequent involvement of SI Joint
      • 100% Involvement of SI Joint
      • Sacroiliitis
        • Important sign for Sernogative Spondyloarthritides
    • Peripheral Inflammatory arthropathy or arthritis
      • 50-70% cases
    • Association with HLA B27
      • HLA B27 Human Leukocyte Antigen
      • 95-97%
        • HLA B27 for Ankylosing Spondylitis
      • 5-7%
        • General Population

Comments

► Comments for document "CNS Infections"

	Kathleen Sundmark almost 4 years ago	Great info. Lots of work. Thank you for these maps. They represent a lot of information and a great deal of work.

	Edward Shekhter almost 4 years ago	Re: Great info. Lots of work. Thank you. Just got NovaMind about 3 weeks ago. This is my first go at it. There is so much information, but I am not sure if the way I presented/did this is the best way. Also I am looking for more insight and better way to do these mind maps, from experienced people.

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