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Syphilis (Aka Lues)

CNS Infections>

Mind Map branch: Syphilis (Aka Lues) Syphilis (Aka Lues) 3 Stages (Primary/Secondary is Curable/Treatable) Primary Hard Canker on site of invasion 3-4 weeks after contact w/host Painless Crater Appearance w/Lymphadenopathy Local Lymphandenopathy Enlargement with or without pain Typically Groin Serological Test = Negative No antibodies found against syphilis infection Secondary Appears 2 months after Primary Infection Involves Generalized Lymphadenopathy (not always visible) Involves Groin & Cervical Area Chronic Leptomeningitis Develops Skin Rash Papule/Pustule Palms or Feet Specific Rash Wet and White Wet portions of body Vaginal Area Condylomata Lata (Venereal Warts) Very Contagious Serological Tests = Highly Positive Spread = Opening into blood stream Last 2 months and subsides Tertiary Appears 10-15 yrs after secondary Subsides 2 Systems CardioVascular 80% (Aka Syphilitic Aortitis) Dramatic change in Wall of Aorta (Ascending Arch) Enlargement & Sclerotic Surface of Aorta Wall Predisposition to Thrombus Rough Surfaces promotes Platelets Develops Aortic Insufficiency (syphilis #3 cause of this) Low Diastolic Pressure DeMusette's Syndrome (stetho on head jumps) Neurosyphilis 10% (Aka Tabes Dorsalis) Involves Brain and SC Posterior Horn of SC (sensation) Numbness and tingling (Nerve root compression/irritation) Brain = Atrophy of Gray Matter Loss of Cognitive Process Called General Paresis (Aka General Paresis of Insane) Chronic Subdural Hematoma Gummateous Necrosis or Liquifactive Necrosis or Caseous Necrosis

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